Dinoprost (Prostaglandin F2) Brands
Dosages;
Combinations; See below
Dinoprost (Prostaglandin F2) Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Prostin F2 | Pfizer Global Pharmaceuticals | Surgipharm Ltd | 5mg | 1ml | Injection | per vial | KES 1,769.00 |
| Dinoprost (Prostaglandin F2) More info | |
|---|---|
| Mode Of Action | Stimulation of gravid uterus to produce myometrial contractions e.g. carboprast |
| Drug Indication | Induction of labour; elective abortion (between 12-18 weeks of gestation); treatment of incomplete abortion; therapeutic abortion (e.g. in cases of intra-uterine fetal death and congenital abnormalities incompatible with life); injected intra-arterially for use as a vasodilator to assist in angiography |
| Precautions | Pregnancy termination can fail; history of anaemia; hypertension or hypotension; cardiovascular disease; diabetes mellitus; renal disease; pre-eclampsia; uterine fibroids; cervical stenosis; uterine surgery; epilepsy; glaucoma; multiparity. |
| Contra-Indications | Allergic reaction to dinoprost or related drugs; history of asthma; active pulmonary disease; significant cephalopelvic disproportion; malpresentation of fetus; active pelvic inflammatory disease; ruptured membranes. |
| Side Effects | Anaphylaxis; bronchoconstriction; burning eyes; endometritis; second-degree heart block; urinary retention; bradycardia; adynamic ileus; peripheral vasoconstriction; tachycardia; and increased uterine bleeding or pain; severe and continuing abdominal or stomach pain; double vision; dysuria; hematuria; paresthesias; leg, back, chest, or shoulder pain. |
| Dosage | As an abortifacient agent: 40mg (base) intra-omniotically (the first 5mg is given at a rate not exceeding 1mg per minute to determine sensitivity and to confirm that the medication is not being administered intravascularly. The remaining 35mg is given over the next 5 minutes. 10-40mg (base) can be given 24hrs after the initial dose if the abortion process is not established or completed as long as the membranes are still intact. Induction of labor: IV infusion 2.5 mcg per minute (when required, the dose can be doubled hourly to maximum of 20 mcg per minute to maximum total dose of 1 - 4 mg). |
| Drug Category | DRUGS ACTING ON GENITO-URINARY SYSTEM |
| Drug Sub-Category | Drugs acting on uterus |